In San Francisco, stock market executive Nick Halloway does not like commitment and is a man with no family and few friends. One day, he goes to the bar and meets his friend George Talbot, who invites him to join his table with his wife and their friend Alice Monroe. Soon Nick and Alice make out in the ladies' toilet and when Alice leaves the bar, Nick drinks too much. The next morning, the hungover Nick must visit his client, Magnascopic Laboratories, and he decides to take a nap in the bathroom, but there is an accident in the building and he does not hear the alarm for evacuation. Soon part of the building and Nick become invisible. When rogue CIA agent David Jenkins finds that Nick is invisible, he convinces his supervisor Warren Singleton (Stephen Tobolowsky) that Nick would be important to study, so he must be captured, and he chases Nick everywhere. Meanwhile, Nick is seeking Dr. Bernard Wachs, expecting that he can restore his visibility. Will he succeed?