Shortly after the events of "Spider-Man: No Way Home", Doctor Strange has been having unusual dreams about a young teenage girl with the ability to open inter dimensional portals. Strange soon learns that America Chavez is the teenager with that ability. In order to learn more about the multiverse, Strange decides to enlist Wanda, who has been in hiding since the Westview incident in "WandaVision". But Stephen soon learns that Wanda has studied the Dark Hold and she is fixated on obtaining America's powers so that she can reunite with her children in a different universe. Stephen's effort on protecting America leads to them being stranded on Earth-838. Stephen decides to rely on an alternate version of Christine Palmer on getting the Book of Vishanti, which is located in the gap junction, so that America can have better control over her powers, but at the same time Stephen must figure out how to free Wanda from the Dark Hold before she destroys the multiverse.