A hybrid vampire known as Blade sweeps the vampire underworld in vampire nightclubs and in the dark streets of New York City because of his hate of vampires that killed his mother in birth with the help of his weapons manufacturer Abraham Whistler. When Blade meets a Hematologist that was bitten by one of his sworn enemies he brings her to his lair and she meets his friend that gave her an antibiotic that reduces the vampire blood spread in her body he frees her but soon realizes she's not safe and discovers she could help him by creating a cure that could heal his blood thirst diseases they go on a mission to stop the neurotic bloodthirsty Deacon Frost, a turned vampire, from summoning the evil spirit of La Magra a Blood King that will sweep New York and eventually the world with it's army of vampire spirits.