Doug McCallister, a creative wedding videographer, is convinced that his career is going nowhere fast. Of course, he is unaware that a blast from the past in the form of a forgotten VHS tape is about to rekindle his dormant interest in making a movie. When his struggling actor best friend Griff announces that he has somehow secured the rights to the horror classic Anaconda (1997), Doug jumps at the opportunity to pursue his childhood Hollywood fantasy. With a mind brimming with ideas and excitement, a four-member crew arrives in the vast Amazon rainforest, the home of mysterious herpetological wonders, to make a spiritual sequel. However, shooting an independent, self-financed film takes guts and luck. What if things don't go as planned? And what if the star of the show, the monstrous giant reptile, never shows up?