1858, somewhere in Texas. With nothing but sweet savage revenge keeping him going, whip-scarred slave Django strikes a mutually beneficial deal with Dr King Schultz, a smooth-talking dentist-turned-bounty-hunter with a lightning-fast right hand. And just like that, the two men join forces to track down the slave-trading Brittle Brothers, ruthless jackals responsible for selling Django's lost love, Hildi, to seasoned slavers. But no one knows Hildi's whereabouts, let alone her fate. As the deadly travelling companions embark on a perilous rescue mission in the Deep South two years before the Civil War, they eventually set foot on vile Mississippi cotton plantation owner Calvin Candie's den of vipers. Now, death lurks around every corner. When the impatient spirit of vengeance demands payback, who can stand in the way of a man passionate enough to attempt the impossible?