In 1965, in New York City, the housewife Rosemary Woodhouse and her husband, the actor of commercials Guy Woodhouse, move to the Bramford building to the former apartment 7E of Mrs. Gardenia on the seventh floor. The lady died after three weeks in coma and Rosemary and Guy intend to have children of their own. They renovate the apartment, and Rosemary befriends the dweller Terry in the laundry, who speaks highly of Minnie Castevet and Roman Castevet, who rescued her from the streets and treat her like a daughter. Soon Terry commits suicide, and Rosemary tells the police officer that the girl loved Mr. and Mrs. Castevet. Minnie invites Rosemary and her husband to have diner with her and Guy goes, despite the initial complaint to the invitation. He immediately befriends Roman, and soon he has sex with Rosemary fainted while she has weirdest dreams. She gets pregnant and Minnie asks her to change her obstetrician to the famous Dr. Sapirstein, who prescribes herbs prepared by Minnie instead of vitamins to her. She begins to wither away with pain and when her friend Edward "Hutch" Hutchins visits her, he is impressed with her appearance. He schedules a lunch with Rosemary to show his discoveries, but he never appears, and she learns that he is in coma. When she meets a common friend at his funeral, she gives a book to Rosemary that Hutch asked her to give while he was in coma. Soon Rosemary learns that the Bramford is a coven and Roman is the son of a notorious devil worshiper. She believes her baby is in danger and tries to escape from the witches. But who can help her?