Medieval Japan at the dawn of the Iron Age. Touched by the indelible stigma of darkness, noble defender of good Prince Ashitaka embarks on a long and perilous quest to face his destiny after a nearly fatal encounter with a raging demon. But with Mother Nature in disarray and his combat hand poisoned to the bone, the brave protector can only pray for a miracle to lift the deadly curse on his arm. After all, murderous ambition and senseless extermination ravage the land. As life slowly succumbs to chaos and barren landscapes replace the lush green forests of old, Ashitaka soon finds himself caught in the middle of a destructive conflict between humankind and omnipotent nature's ancient gods. Now, Lady Eboshi, the bellicose leader of the Iron Town, stands in the way of resolution. With the future of all living things hanging by a thread, can the banished young warrior count on the feral Wolf Girl to restore peace?