With everyone around him dead and Gamora's tragic demise in Avengers: Infinity War (2018) etched on his mind, a broken Peter Quill drowns his sorrows in Knowhere, the Guardians' headquarters. But life and time wait for no one. And as a devastating blow comes out of nowhere, leaving a dear friend incapacitated, the depressed Star-Lord must pull himself together to assemble his crew for one last life-and-death mission. This time, however, it seems the space defenders have bitten off more than they can chew. They say the third time's the charm. But with the dark past catching up with them, can the Guardians of the Galaxy (2014) thwart the sinister plans of an unstoppable intergalactic megalomaniac? Can they save the universe one more time?