Ramona Knox is a rookie FBI agent with a special advantage - since she was a little girl, Ramona has been visited by a suited man nobody else can see. This man claims to be Death, something the newly minted agent’s relationship with him will continuously transcend and defy. As Ramona’s lifelong friendship with the Grim Reaper develops, joining them to a suicidal immortal upon whose fragile state their destinies are hinged, the trio must face a deadly virus within an alternate timeline; fight a shadowy cabal in a cosmic metropolis, and defend Earth from complete annihilation when all of creation is threatened by a resentful, banished god and his army of dragons.